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Methylation is a chemical process in the body where methyl groups (CH3) are added to certain proteins to aid in their assimilation. This process is crucial for some biological functions because it makes the proteins in question easier to absorb. Methylated multivitamins are easier for the body to process than regular multivitamins.
In this article, we’re going to introduce you to some of the best methylated multivitamin options, starting with Double Wood Methylated Multivitamin. We’ll also show why they might be a better choice than a regular multivitamin.
Methylated vitamins have gained attention for their enhanced bioavailability, particularly for individuals with specific genetic variations. But what are they, and why do they matter?
As we mentioned, a methylated vitamin has a methyl group (CH3) attached to its chemical structure. This process makes the vitamin more active, making it easier for the body to absorb.
Methylated vitamins are in a form that can be immediately used by the body. Regular vitamins need to be broken down by the body’s chemical processes first before they can be utilized.
Those with genetic variations like the methylenetetrahydrofolate reductase (MTHFR) gene can have difficulty converting folate to its more active and usable form. This is important because folate is instrumental in changing the amino acid homocysteine to the more usable amino compound known as methionine. Methylated vitamins help individuals with the MTHFR gene break down folate more effectively.
Reviews/Ratings: 147 reviews on Trustpilot
Product Name: Methylated Multivitamin
Product Provider: Double Wood
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Reviews/Ratings: No reviews on Trustpilot
Product Name: Methylation Support
Product Provider: Akasha Naturals
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Reviews/Ratings: 7 reviews on Trustpilot
Product Name: Multivitamin Immune
Product Provider: Ancient Nutrition
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Reviews/Ratings: No reviews on Trustpilot
Product Name: B6 B12 Methyl Folate
Product Provider: KAL Vitamins
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In the following sections, we’ll carefully review each brand on our list, exploring each company’s background, why the products stand out, their promotional offerings, and how to reach their support team.
This popular brand that uses the slogan “rooted in science, grounded in transparency,” Double Wood Supplements has been providing top-grade vitamins since 2013 when twin brothers Reese and Evan Wood founded the company.
This methylated multivitamin contains all the B vitamins essential for optimum absorption and cellular synthesis. These include activated forms of B6, folic acid, B12, and TMG, a methylated amino acid.
All of the above play essential roles in cellular maintenance and energy production, ensuring that your body receives these essential nutrients in their most accessible and effective forms, which ultimately contributes to your overall health and well-being.
Double Wood is also 100% transparent, providing the certificate of analysis (COA) and all third-party testing results on their website. The multivitamin is also gluten-free and non-GMO, appealing to health-conscious consumers and those following a structured diet program.
A single purchase of a 120-capsule bottle sells for $29.95. Subscribers pay $23.96 per bottle and save 27% on a double pack and 29% on a triple pack. Plus, there’s a 30-day refund policy on your first bottle and free shipping on all U.S. orders.
Double Wood customer support is available via email, an on-site contact form, and via phone at 570-437-0203.
Akasha Naturals, an off-shoot of the Akasha Center for Integrative Medicine, was founded in 2002 by Dr. Edison de Mello. As an extension of the Center, the Akasha Naturals brand is all about empowering you to take control of your health in a holistic, integrated way.
Methylation is a process that cells use to make biochemical conversions to protect, repair, and enhance the workings of our immune system. This comprehensive Akasha Naturals formula features all the B vitamins involved in this cellular process in their most assimilable and effective biochemical forms.
This includes calcium L-5 methyltetrahydrofolate, N-acetyl-L-cysteine, methylated B6 and B12 vitamins, betaine HCI, and added manganese, zinc, and molybdenum.
In layman’s terms, these nutrients help to assist cellular repair, maintain a healthy immune system, produce glutathione, the body’s primary antioxidant, and so much more.
A one-time purchase of a 120-capsule bottle of Methylation Support costs $57.25. Free shipping is available until April 31, 2025.
You can contact Akasha Naturals Support via online form, email, or phone at 310-451-7775.
Believing in the human body’s potential for high performance and wanting to establish a support system for that, Ancient Nutrition was founded in 2016 by Jordan Rubin and Dr. Josh Axe. Since then, products like their Multivitamin Immune have been making life a little healthier for all of us.
Containing 21 vitamins and minerals, more than a half-dozen superfoods, plus beef liver and wild hake roe, Ancient Nutrition’s Multivitamin Immune delivers dense and easily accessible nutrition.
As a result, you can depend on the highest level of support for optimum immune health, a healthy stress response, and superior cardiovascular and bone health. It also helps to elevate cognitive function.
A one-time purchase of a 90-capsule bottle of Multivitamin Immune costs $49.95. Subscribers save 15% plus free delivery.
Customer service can be reached via email or text. You can also phone 1-855-803-1275 between 7 a.m. and 6 p.m. CST Monday through Friday and 8 a.m. and 4 p.m. CST Saturday.
OverviewSince Chester Weldon discovered a calcium and phosphorous powder for his wife’s leg cramps back in the day, KAL has been supplementing America’s growth since 1932. And they’re still on the cutting edge in the nutritional and supplement biz with their B6 B12 Methyl Folate supplement. Let’s check it out.
If you want to ensure the B vitamin supplements you’re taking are doing what they’re supposed to, then the KAL B6 B12 Methyl Folate supplement should be your choice.
The special methylated forms of these essential B vitamins will provide the nutritional support you need for improved cardiovascular function and better red blood cell synthesis. In addition, evidence suggests that methylated B vitamins are potentially helpful for slightly enhancing mood and mental health in adults battling depression.
Plus, they’re easy to take. No mixing drinks or big pills to swallow. Just place 1 tablet per day under your tongue and let it dissolve for maximum absorption.
A one-time purchase of a 60-micro tablet bottle of KAL B6 B12 costs $$16.95.
KAL customer support is available via their online form or by phone and mail at 1-800-538-5888 and [email protected].
Choosing the right methylated multivitamin involves understanding your needs and the nuances of these specialized supplements. Here’s a breakdown of key considerations:
Methylated vitamins are not the norm in the supplement business. That means it is important to check the label of what you’re buying to make sure the B vitamins you’re getting are in their most natural and easily absorbable form. You also need to check how all the ingredients included are sourced and that they have been verified by third-party testing.
Methylated vitamins are naturally occurring forms of vitamins found in whole food sources. Synthetic vitamins are much less effective because they are created in the laboratory and designed to mimic the quality of naturally occurring vitamins. They may also carry a higher risk of side effects.
Nature is a continually interactive and cooperative environment where multiple life forms support and enrich each other. When you buy any methylated vitamin, it is important that you get not only the necessary B vitamins in their purest forms but also other essential supplements and nutrients like zinc and magnesium. Also, don’t forget to eat a balanced diet.
Third-party testing by an impartial and non-vested organization is important to ensure that you’re getting the purest and highest-quality nutrients available, not just a well-written line of advertising from the manufacturer.
Methylation is a crucial biochemical process that impacts numerous bodily functions, from DNA synthesis to neurotransmitter production. Methylated nutrients play a vital role in supporting this process. Some key players include:
Also known as methylcobalamin, Methylated B12 helps produce red blood cells, supports brain and nerve health, lowers homocysteine levels, and increases cognitive functioning.
Also known as L-5-MTHF or L-Methylfolate, Methylfolate (vitamin B9) is essential for healthy conception in women, fetal development, DNA formation, prevention of neural tube defects, and more. In men, Methylfolate can aid in improving heart health and balancing iron levels [1].
Also known as PLP, this is an active form of vitamin B6 that is essential for amino acid metabolism. It is also necessary for the production of neurotransmitters like serotonin and dopamine, as well as hemoglobin synthesis and proper immune functioning [2] [3].
Also known as R5P, Riboflavin is a form of vitamin B2. It is instrumental in metabolizing energy and assisting in cell growth development. It also plays an important role in oxidizing omega fatty acids and carbohydrates, producing DNA and RNA, and lowering glutathione levels [4].
Here as the key benefits:
Methylated mulitivitamin can be particularly beneficial for:
Now, let’s see what actual users had to say about their experiences using the various methylated multivitamin brands we’ve reviewed.
On the website, one customer, Yaaqoub G, praises Double Wood Methylated Multivitamin for supporting their active lifestyle, even into their 60s. However, another customer, Liz, mentioned an unpleasant aftertaste that sticks around longer than they’d like [7].
One customer wrote on the official site that she felt Akasha was the best. Before she started using it regularly, she was sick all the time. Meanwhile, another customer appreciated the benefits but wished it had fewer extra ingredients [8].
One reviewer on Trustpilot, Linda, declared that she has been a loyal customer of Ancient Nutrition for many years and feels their products are absolutely fabulous [9]. However, Susan was not satisfied, stating that she found the taste unpleasant and that it didn’t dissolve well [10].
One reviewer on Amazon says they’ve been using KAL for over 20 years and wouldn’t buy any other brand. In particular, the B6 B12 Methyl Folate is very potent [11]. Another user loves the taste and easy dissolvability of B6 B12 Methyl Folate but criticizes the excessive plastic packaging [12].
Here are some questions that customers are asking about the best methylated multivitamin brands.
A methylated multivitamin is one that has a methyl group (CH3) attached to the chemical structures of the various vitamins it contains. This process makes the vitamins included in the supplement more active, making it easier for the body to absorb them.
Because the body more easily absorbs the methylated form of a vitamin, they can be better for some individuals, such as:
You should always consult with your doctor before taking any supplement, but if any of the following apply to you, it is possible that you need a methylated multivitamin:
No, the Olly company does not manufacture any methylated vitamin products.
Methylated Vitamins should be avoided by the following groups of people:
The body absorbs methylated multivitamins more easily, but since everyone is different, especially those with potential vitamin deficiency, it would be wise to consult with your physician before taking them daily.
Yes, there are methylated multivitamins designed to support children’s nutritional needs. They are often marketed to parents as kids multivitamins to ensure optimal nutrient absorption for their children. It’s always crucial to consult with a pediatrician or your healthcare provider before giving any new vitamin or supplement to a child.
Now that you know more about methylated multivitamins and how they can make it easier for the body to absorb essential B nutrients, what do you think?
If it seems like a methylated multivitamin would be helpful, you should contact your doctor and see if they think it would be right for you.
All of the supplements we’ve suggested, including our top pick, Double Wood Methylated Multivitamin, are of the highest quality. They use cutting-edge science and the best ingredients.
Happy hunting and good health!
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